An enantiomer-enantiomer interaction of (S)- and (R)-propafenone modifies the effect of racemic drug therapy.
نویسندگان
چکیده
منابع مشابه
An enantiomer-enantiomer interaction of (S)- and (R)-propafenone modifies the effect of racemic drug therapy.
BACKGROUND Therapy with racemic compounds produces effects that can be attributed to both (S)- and (R)-enantiomers. Here we have tested the hypothesis that an enantiomer-enantiomer interaction would modulate the effects of treatment with a racemate, the antiarrhythmic propafenone. Previous studies have shown that while the enantiomers of propafenone exert similar sodium channel-blocking (QRS wi...
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ژورنال
عنوان ژورنال: Circulation
سال: 1994
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.89.5.2396